IGH/C-MYC PLUS TRANSLOCATION, D

Código: RULPH076 - Referência: IGH/C-MYC PLUS TRANSLOCAT

SOLICITE SEU ORÇAMENTO

COMPARTILHAR:

Applications
Haematology
 
Catalogue Numbers
LPH 076 (10 tests)
LPH 076-S (5 tests)

The cMYC(MYC)/IGH translocation t(8;14), and the variant forms t(2;8)(p13;q24) and t(8;22)(q24;q11), are found in Burkitt's lymphoma and mature B-cell or Burkitt's type Acute Lymphoblastic Leukaemia (ALL)1.

The t(8;14) is the most common and is found in approximately 85% of patients with Burkitt's lymphoma2. While translocation breakpoints on chromosome 14 are clustered to a narrow region 5' to the intron enhancer of the immunoglobulin heavy chain, the breakpoints on chromosome 8 can occur more than 340kb upstream of MYC, with no preferential site3. The translocation brings MYC into close proximity to the IgH enhancer and results in the up-regulation of MYC4. Over expression of the transcription factor stimulates gene amplification resulting in uncontrolled cell proliferation, which usually occurs in the late event of tumour progression5.

In our hands, Cytocell FISH probes, have proven to be of the highest quality with bright, easy to interpret signals, thus providing confidence in our results. Cytocell’s customer support is outstanding, as their staff are extremely knowledgeable and truly care about their customers and their customers’ needs. Jennie Thurston, Director of Cytogenetics at Carolinas Pathology Group

References

1. Berger R, Bernheim A, Cancer Genet Cytogenet 1982;7(3):231-44

2. Hoffman, Ronald (2009). Hematology : basic principles and practice (5th ed. ed.). Philadelphia, PA: ChurchillLivingstone/Elsevier. pp. 1304–1305

3. Joos et al., Human Molecular Genetics 1992;1(8):625-32

4. Erikson J et al., Proc Natl Acad Sci USA 1983;80(3):820-4

5. Shou et al., PNAS 2000;97(1):228-33


avalie este produto Sua opinião é muito importante para nós