LPS011 – CYTOCELL RB1 DELETION

Probe Information
Retinoblastoma (Rb) is a cancer of immature retina cells that occurs in infants and small children1. The protein encoded by the 180kb Retinoblastoma 1 (RB1) tumour suppressor gene, located on 13q14.2, may form complexes with oncoproteins and block their tumourigenic activity2. Deletion of this gene, particularly homozygous deletion, is therefore a causal event in the development of retinoblastoma. The RB1 gene also plays a role in secondary tumours arising in retinoblastoma patients, such as osteosarcoma and some soft tissue sarcomas3. The RB1 gene may also be deleted as a result of a progressional tumourigenic event in some leukaemias4, as well as in some breast, lung, bladder, oesophagus and prostate cancers5.
Probe Specification
RB1, 13q14.2, Red
13qter, 13q34, Green

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