NucleoSpin® Bead Tubes
Our solution for RNA or DNA purification from hard to lyse sample materials
Since years MACHEREY-NAGEL is well known for expertise in purification of high quality RNA and DNA from a wide range of samples. Efficient lysis of starting material is crucial for obtaining desired amounts of highly pure RNA and DNA. Difficult to lyse sample materials are often associated with low yield of nucleic acids which and many scientists are faced with such situations nearly every day.

MN has now utilized its experience in RNA and DNA purification and has developed several NucleoSpin® Bead Tubes for efficient sample homogenization. These NucleoSpin® Bead Tubes are provided in different variants (e.g., glass beads, corundum, steel beads) appropriate to the respective application and/or sample material.
For example, the NucleoSpin® Bead Tubes Type A are recommended fo homgenizing soil and sediments. Together with NucleoSpin® Bead Tubes Type G , being highly efficient in disrupting plant material,  these bead tubes are very interesting for scientists working on metagenomic studies. The NucleoSpin® Bead Tubes Type B and C are of use for researchers working on microbiome analysis as these tubes can be used for the lysis of microbial organisms. NucleoSpin® Bead Tubes Type F are intended for clinical samples, especially for difficult to lyse tissue samples such as spleen or lung material. Even for insects, a special NucleoSpin® Bead Tube Type D is available.

The NucleoSpin® Bead Tubes are already included in specific kits for RNA or DNA purification depending on the application. MN provides e.g., the NucleoSpin® DNA Insect kits with NucleoSpin® Bead Tubes Type D or the NucleoSpin® RNA Stool kit with NucleoSpin® Bead Tube Type A.

The NucleoSpin® Bead Tubes can be used with common bead mills (for details see NucleoSpin® Bead Tubes user manual). In addition, MN provides a MN Bead Tube Holder to enable an easy sample disruption on a Vortex-Genie® 2.

ProductSpecificationTo be used withIn conjunction with  REF
NucleoSpin® Bead Tubes Type A0.6-0.8 mm ceramic beads, for homogenization of soil, sediments, and stoolNucleoSpin® Soil, NucleoSpin® Stool, NucleoBond® RNA Soil, NucleoSpin® RNA Stool
MN Bead Tube Holder or mixer mill* 740786.50

NucleoSpin® Bead Tubes Type B

40-400 µm glass beads, for homogenization of Gram-positive and Gram-negative bacteriaNucleoSpin® Microbial (included)MN Bead Tube Holder or mixer mill* 740812.50
NucleoSpin® Bead Tubes Type C1-3 mm corundum,
for homogenization of yeast and fungi
NucleoSpin® Microbial (included)MN Bead Tube Holder or mixer mill* 740813.50

NucleoSpin® Bead Tubes Type D

3 mm steel beads,
for homogenization of insects, crustaceans, lipid-rich tissue
NucleoSpin® DNA Insect, NucleoSpin®DNA Lipid Tissue (included)MN Bead Tube Holder or mixer mill* 740814.50

NucleoSpin® Bead Tubes Type E

3 mm steel beads and 40–400 μm glass beads,
for homogenization of bacteria within insects or tissue samples
NucleoSpin® DNA Insect, NucleoSpin®DNA Lipid Tissue (optional)MN Bead Tube Holder or mixer mill* 740815.50
NucleoSpin® Bead Tubes Type F1-3 mm corundum and 3 mm steel beads,
for homogenization of challenging tissues, e.g., spleen, or lung tissue
NucleoSpin®DNA RapidLyse (optional)MN Bead Tube Holder only!740816.50
NucleoSpin® Bead Tubes Type G5 mm steel beads,
for homogenization of plant material
NucleoSpin® RNA Plant and Fungi (optional)Mixer mill*740817.50
Product accessoriesSpecification  REF
MN Bead Tube Holderto house up to 12 bead tubes in combination with a Vortex-Genie®instrument740469

*If using a bead mill, respect warnings, in the NucleoSpin® Bead Tubes user manual!


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