MAF (MAF bZIP transcription factor) gene is located at 16q23 and IGH (immunoglobulin heavy locus) at 14q32.3. Approximately 50-60% of multiple myeloma (MM) cases are associated with translocations involving IGH and one of several partners including CCND1, NSD2 (WHSC1)and FGFR3, CCND3, MAF or MAFB1 . The t(14;16)(q32.3;q23) translocation is a recurrent translocation seen in 2-10%of MMs1 . The majority of the breakpoints occur within the last intron of WWOX (WW domain containing oxidoreductase), centromeric to MAF. These breakpoints have a dual impact of positioning the IGH enhancer near MAF and disrupting the WWOX gene2 . Gene expression profiling of myeloma cell lines revealed that MAF caused transactivation of cyclin D2 (a promoter of cell cycle progression), thus enhancing proliferation of myeloma cells3 . According to the literature, MM patients harbouring the t(14;16) appear to have a more aggressive clinical outcome4,5 .
Probe Specification MAF, 16q23, Red IGH, 14q32.3, Green
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