Probe Information
SRY (sex-determining region Y), located in band Yp11.31, is the genetic master switch of mammalian sex determination1. It encodes a transcription factor that is a member of the high mobility group (HMG) -box family of DNA binding proteins2. In mammals, it triggers the development of undifferentiated gonads into testes3. Human zygotes with mutations in SRY develop into XY females, while XX zygotes in the presence of SRY develop a male phenotype with occasional ambiguous genitalia4,5. Translocations of X and Y are rarely reported but often lead to sex reversal6.
Probe Specification
SRY, Yp11.31, Red
DYZ1, Yq12, Green
DXZ1, Xp11.1-q11.1, Blue


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